The Kim Lab

at the University of Toronto

 

Dr. Junchul Kim

2005~2010 - Postdoctoral Research Fellow, Genetics Department, Harvard Medical School, USA.

2005 - Ph.D. in Molecular biology and Biochemistry, Simon Fraser University, Canada.

1996 - B.Sc. in Biology, Yonsei University, Seoul, Korea.

We are interested in understanding how the brain is wired for processing information from the environment to generate approach-avoidance behaviours, with a particular focus on neuronal circuits that modulate behaviours associated with anxiety and schizophrenia. Using the mouse as a model organism, we are currently using various genetic approaches for neuron manipulation, including opto- and pharmacogenetics. We hope that the resultant findings yield new insights into the pathophysiology of schizophrenia and anxiety-related disorders and potentially provide new therapeutic targets for their treatment.

ANIMAL BIOLOGY - GENETICS - MOLECULAR BIOLOGY - NEUROBIOLOGY - PSYCHOLOGY - BEHAVIOUR

 
 

GRADUATE STUDENTS

 

Robin Nguyen

rt.nguyen89@gmail.com

Dept. of Psychology

 

Afif Aqrabawi

afif.aqrabawi@mail.utoronto.ca

Dept. of Cell and Systems Biology

 

Janine Dominique Cajanding

j.cajanding@mail.utoronto.ca

Dept. of Cell and Systems Biology

 

June Bang

jee.bang@mail.utoronto.ca

Dept. of Cell and Systems Biology

 

 

Alumni Members

Dr. Paul Whissell- postdoctoral fellow

Dr. Gustavo Morrone Parfitt - postdoctoral fellow

Sabrina Nawaz - research student

Ikram Khan -lab manager

Golsa Shafa - undergraduate student

Shubham Sharma - undergraduate student

Brian Pereira - undergraduate student

Cheryl Lau - undergraduate student

Joanna Zhou - undergraduate student

Chloe Briggs - undergraduate student

Waldo Lefever - undergraduate student

 

Publications

Parfitt GM, Nguyen R, Bang JY, Aqrabawi AJ, Tran MM, Seo DK, Richards BA, Kim JC. Bidirectional Control of Anxiety-Related Behaviours in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex. Neuropsychopharmacology. 2017 Mar 15.

Aqrabawi AJ*, Browne CJ*, Dargaei Z, Garand D, Khademullah CS, Woodin MA, Kim JC. Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus. *These authors contributed equally to this work. Nature Communications. 2016 Dec 22;7:13721.

Cloke JM, Nguyen R, Chung BY, Wasserman DI, De Lisio S, Kim JC, Bailey CD, Winters BD. A Novel Multisensory Integration Task Reveals Robust Deficits in Rodent Models of Schizophrenia: Converging Evidence for Remediation via Nicotinic Receptor Stimulation of Inhibitory Transmission in the Prefrontal Cortex. J Neurosci. 2016 Dec 14;36(50):12570-12585.

Wasserman DI, Tan JM, Kim JC, Yeomans JS. Muscarinic control of rostromedial tegmental nucleus GABA neurons and morphine-induced locomotion. Eur J Neurosci. 2016 Jul;44(1):1761-70.

Okaty BW, Freret ME, Rood BD, Brust RD, Hennessy ML, DeBairos D, Kim JC, Cook MN, Dymecki SM. Multi-Scale Molecular Deconstruction of the Serotonin Neuron System. Neuron. 2015. 88, 774–791.

Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. (2015). A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. elife (4): e04718.

Whissell, PD, Cajanding, JD, Fogel, N, & Kim JC. Comparative density of CCK- and PV-GABA cells within the cortex and hippocampus. Front. Neuroanat. 2015 Aug 31;9(124):

Nguyen R, Morrissey MD, Mahadevan V, Cajanding JD, Woodin MA, Yeomans JS, Takehara-Nishiuchi K, Kim JC. Parvalbumin and GAD65 Interneuron Inhibition in the Ventral Hippocampus Induces Distinct Behavioral Deficits Relevant to Schizophrenia. J Neurosci. 2014 Nov 5;34(45):14948-60.

Heimer-McGinn V, Murphy AC, Kim JC, Dymecki SM, Young PW. Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo. Neurosci Lett. 2013 Oct 25;555:36-41.

Ray RS*, Corcoran AE*, Brust RD*, Kim JC, Richerson GB, Nattie E, Dymecki SM. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. *Equal contribution. Science. 2011 Jul 29;333(6042):637-42. 

Dymecki SM, Ray RS, Kim JC. Mapping cell fate and function using recombinase-based intersectional strategies. Methods In Enzymology. 2010; 477:183-213.  

Kim JC, Cook MN, Carey MR, Shen C, Regehr WG, Dymecki SM. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron 2009; 63 (3):305-15.

Kim JC, Dymecki SM. Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus. Methods Molecular Biology 2009 (493):65-85. 

Dymecki SM, Kim JC. Molecular neuroanatomy's "Three Gs": a primer. Neuron 2007; 54 (1): 17-34.

Kim JC*, Badano JL*, Sibold S*, Esmail MA, Hill J, Hoskins BE, Leitch CC, Venner K, Ansley SJ, Ross AJ, Leroux MR, Katsanis N, Beales PL. The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. *Equal contribution. Nature Genetics 2004 May; 36(5):462-70

Kim JC, Ou Y, Badano JL, Esmail MA, Leitch CC, Fiedrich E, Beales PL, Archibald JM, Katsanis N, Rattner JB, Leroux MR. (2004) MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis. Journal of Cell Science 2005 Mar; 118(5):1007-20. 

Ansley JS*, Badano JL*, Blacque OE*, Hill J, Hoskins BE, Leitch CC, Kim JC, Ross AJ, Eichers ER, Teslovich TM, Mah AK, Johnsen RC, Cavender JC, Lewis RA, Leroux MR, Beales PL, Katsanis N (2003). Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome. *Equal contribution. Nature 2003 Oct 9; 425(6958): 628-33.

Badano JL, Kim JC, Hoskins BE, Lewis RA, Ansley SJ, Cutler DJ, Castellan C, Beales PL, Leroux MR, Katsanis N. Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus. Human Molecular Genetics 2003 Jul 15; 12(14): 1651-9. 

Han SY, Kim JC, Chung IK Cell type-dependent regulation of human DNA topoisomerase III alpha gene expression by upstream stimulatory factor 2. FEBS Letter 2001 Sep 7; 505(1): 57-62.

Kim JC, Yoon JB, Koo HS, Chung IK (1998) Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene. Journal of Biological Chemistry 273: 26130-7.

Son YS, Suh JM, Ahn SH, Kim JC, Yi JY, Hur KC, Hong WS, Muller MT, Chung IK. Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell line. Cancer Chemotherapy and Pharmacology 1998, 41: 353-60.

Contact

PHONE

Lab: (416) 978-3403 

Office: (416) 978-4260

LOCATION

Room 4028, Sydney Smith building, 100 St George street

Psychology Department, University of Toronto

Toronto ON, Canada

M5S 3G3 

EMAIL

kim@psych.utoronto.ca